Chapter 128 Rules

Chapter 128 Rules

Chapter 128 Rules (Medium Cup)
December arrived quietly.

The company's various projects are progressing in full swing.

Jiang Miao is still doing various researches.

Originally there were no plans for the next few days, so we were just waiting for Yang Hejun from Chengyi Group to visit on the 6th.

However, at noon on the 3rd, as soon as he came out of the laboratory, he saw a familiar figure talking and laughing with a girl wearing glasses not far away.

"Brother Jianming, what brings you here?"

Upon hearing Jiang Miao's voice, Li Jianming also reacted and said with a smile: "A Miao, long time no see."

After five months of treatment, Li Jianming's complexion improved a lot. Last month, his wife became pregnant and even called to thank Jiang Miao.

"Who is this?" Jiang Miao was a little surprised. After all, the other man's wife had just become pregnant, but the girl in front of him didn't show any signs of pregnancy, and she had serious health problems.

"Let me introduce you. This is He Youwei, the daughter of my father's old comrade-in-arms. She is a native of Beijing, 26 years old this year. She just came back from an exchange program at the University of Melbourne last year. She is a doctoral student in the medical experimental class of Wudaokou University and is currently interning at the Union Hospital." Li Jianming turned his head and looked at the girl:
"Youwei, this is the founder of Hailufeng Company and the inventor of the artificial breeding technology for eels. His wife Lin Shuya is the inventor of the artificial cultivation technology for white truffles."

"Hello! Mr. Jiang!" He Youwei smiled and stretched out her hand.

Jiang Miao shook hands with the other party: "Hello, Ms. He. Brother Jianming, let's go to the restaurant on the second floor to eat and chat!"

"it is good."

The three of them went up to the restaurant's private room on the second floor.

After taking their seats, Jiang Miao asked, "What would you like to eat?"

"You're welcome, a box lunch will be fine." Li Jianming said with a smile. He had eaten box lunches several times at Hailufeng Company and found that the taste was okay, and the key was that it was clean and hygienic.

"Me too." He Youwei nodded.

Jiang Miao turned his head and said, "Zixuan, please help me get some lunch boxes. Get a clerk meal for Brother Jianming, and prepare a special meal for Ms. He."

When Li Zixuan heard about the special meal, he became cautious. He took out a small notebook and a ballpoint pen and asked, "Boss, what should I pay attention to for the special meal?"

"Mr. Jiang, don't bother." He Youwei was a little at a loss.

"It doesn't matter." Jiang Miao smiled and instructed: "No celery, coriander, mushrooms, chili peppers, peppercorns, raw garlic, fried foods, animal offal, or cream products. The rest can be arranged based on the situation."

Li Zixuan took notes quickly, then repeated it. After confirming that it was correct, he quickly went downstairs to arrange the food.

After Li Zixuan left, Li Jianming said, "It seems that you have already figured it out, Miao."

He Youwei on the side was also a little shocked. If she hadn't told Li Jianming not to tell the other party about his situation in advance, she would have suspected whether Li Jianming had informed the other party in advance.

"People with systemic lupus erythematosus still need to pay attention to their diet." As soon as Jiang Miao saw He Youwei, he knew that she had systemic lupus erythematosus.

This disease is an autoimmune disease.

In terms of pathogenesis, the patient's own immune system mistakenly attacks its own tissues and organs.

Under normal circumstances, the immune system can recognize and defend against foreign pathogens, but in SLE patients, the antibodies and immune complexes produced by the immune system will attack the body's own cells and tissues.

In short, the body is always in a state of self-mutilation.

"A Miao, I brought Youwei here this time because I want you to help see if she can be treated with traditional Chinese medicine."

Jiang Miao glanced at He Youwei and then said, "Judging from Ms. He's condition, she should be taking medicine regularly now!"

He Youwei raised her glasses and nodded: "Yes, I currently take hydroxychloroquine and mycophenolate mofetil regularly. If the situation is serious, methylprednisolone will be added."

“Do you feel that the effect of glucocorticoids has weakened, and the side effects are obvious, such as frequent proteinuria?”

Instantly, He Youwei's eyes widened. She remembered very clearly that she had only told Li Jianming that he had systemic lupus erythematosus, but did not tell him the details. She was stunned and nodded immediately: "Yes, I was taking prednisone before, but now I am taking methylprednisolone."

"Let me tell you the truth! A simple treatment plan of traditional Chinese medicine or Western medicine for your disease will not have a very good effect. You are an intern at Union Hospital, so you should be very clear about this."

"I understand." He Youwei's face darkened.

"A Miao, is there really no way?" Li Jianming still cared about He Youwei. After all, when He Youwei was a child, she always followed him, brother in front and brother behind, and the relationship between the two families was very good.

Jiang Miao waved his hand: "Diet therapy alone will not have much effect. Gene target therapy must be carried out."

"Gene targeted therapy? This technology is not very mature now, right?" He Youwei naturally knew about this technology.

To be precise, she previously studied in the Medical Experimental Class of China PBC University because this medical experimental class had an exchange mechanism for international students, allowing them to go to the University of Pittsburgh or the University of Melbourne for exchanges.

The exchange university chosen by He Youwei was the University of Melbourne, where she exchanged and interned with the team of the Peter Doherty Institute of Infection and Immunity.

Over the past 23 years, the team at this institute has discovered a unique mechanism that controls different types of immune cells in the skin, which can distinguish between cells that cause autoimmune diseases and "good" cells that maintain protective immunity, providing a precise target for curing skin diseases such as psoriasis, vitiligo and alopecia areata.

However, He Youwei did not find a way to treat her systemic lupus erythematosus, so she had to return to China to continue her doctoral studies and then intern at the Peking Union Medical College Hospital.

"I know about this technology. Its therapeutic principle is mainly to intervene in specific gene targets related to the disease. For example, targeted regulation of genes related to the immune system can regulate the immune response by interfering with abnormal gene expression or protein function."

"Currently, targeted therapy for B cell activating factor (BAFF) is one of the research hotspots. One of the drugs I am more familiar with is belimumab, which has been approved for the treatment of systemic lupus erythematosus. It can specifically bind to BAFF, reduce the survival and differentiation of B cells, thereby reducing the production of autoantibodies and alleviating the activity of the disease."

"That's right." Jiang Miao nodded.

He Youwei frowned and said, "However, gene target therapy still faces some challenges. I can afford the high cost of treatment, but the possible off-target effects, long-term efficacy and safety are the key issues."

"I can perform this kind of treatment, but there is a problem. I don't have the qualifications to practice medicine, so I need to avoid unnecessary risks." There was a hint of something strange in Jiang Miao's eyes.

After all, Li Jianming's previous treatment used a dietary therapy plan, which was equivalent to a nutritionist's advice and did not require a medical qualification certificate.

However, He Youwei's situation, which involves gene targeted treatment, cannot be fooled by diet therapy.

If someone catches this, it will be easy for them to take advantage of it to cause trouble.

Jiang Miao doesn't want to leave any hidden danger for himself.

Li Jianming and He Youwei also reacted immediately. After all, they both knew a lot of things. Once they were done, as long as someone really wanted to cause trouble, they could take the opportunity to magnify it.

"A Miao, what do you think?" Li Jianming asked directly.

Jiang Miao said his solution: "I will acquire a medical device and pharmaceutical R&D company as a private person, then hire Ms. He as the chief technology officer, and recruit some people with medical qualifications to join. Then, I can conduct treatment in the name of experiments."

"How can I let Mr. Jiang spend so much money? Let's just forget it." He Youwei felt a little embarrassed.

"It doesn't matter. Anyway, I do have the idea of ​​entering the medical industry, but I don't have the energy to manage it." Jiang Miao explained with a smile.

In essence, Jiang Miao's purpose is more than just that.

After all, the domestic medical industry is too complicated and Hailufeng Company is not suitable to enter, so he must bring a qualified person to the platform.

He originally planned to wait a few more years.

He Youwei's current situation made Jiang Miao change his mind. From his observation, she was relatively simple-minded. Perhaps this was because she majored in science and engineering, and because she was weak and sickly since childhood, she did not develop any bad habits. Jiang Miao knew about Li Jianming's family situation. After all, he could collect a lot of information through his means on the Internet.

As far as he knew, Li Jianming's father had two comrades-in-arms with the surname He. When the other party introduced them just now, he said that He Youwei was from Beijing, so her father's identity was very clear.

If He Youwei is willing to join this pharmaceutical company, the troubles in the country will be reduced by 99% instantly, and the remaining 1% can only be due to force majeure.

Rather than being passive at that time, it is better to take the initiative now and find a more suitable partner.

Even though He Youwei was relatively innocent, she could hear the hidden meaning in Jiang Miao's words.

"Youwei, you can rest assured about A Miao's medical skills. Don't hesitate. Besides, A Miao is a law-abiding person and will not use your name to do anything illegal." Li Jianming hurriedly persuaded her.

After all, Li Jianming, who had been with Jiang Miao for some time, knew Jiang Miao's character. In the development process of Hailufeng Company, shortcuts could have been taken many times. If Jiang Miao was willing to speak, it would only take a word. However, he never did so. Instead, he would rather spend a little more money to ensure that all procedures and processes were legal and compliant.

Of course, Li Jianming did this for his own selfish reasons. If He Youwei could be cured, the relationship between the two families could be further improved.

That's why he persuaded He Youwei to join.

He Youwei thought about it for a while and soon figured it out.

"The other party's condition is not a big problem. Anyway, if my health continues like this, it is not a solution. Besides, my brother's health also needs treatment."

Her parents do not have systemic lupus erythematosus, but her grandmother does, so she obviously inherited it from her grandmother.

After the second child policy was implemented, her parents planned to have another baby, so they had an in vitro fertilization in 16, but the result was still disappointing.

After her younger brother was born, he did not show any signs of systemic lupus erythematosus, which made the whole family very happy. However, the good times did not last long. In 22 years, due to an influenza virus infection, her brother's immune cells were stimulated and systemic lupus erythematosus broke out.

At this time, her parents were in their forties, and the risk of having a third child was too great. In addition to the situations of their first two children, they did not dare to have another child for fear of having another child with a genetic disease.

"I can agree to join Mr. Jiang's pharmaceutical company."

"In that case, let's have fun working together." Jiang Miao smiled and stretched out his hand.

The two shook hands again.

At this moment, Li Zixuan also brought up three lunch boxes with a basket. After putting them down, he left consciously and closed the door of the private room.

Jiang Miao took his own portion and handed He Youwei's special meal to her, and the remaining portion was Li Jianming's.

After taking a bite of the meal, He Youwei asked, "Mr. Jiang, how will your treatment plan proceed?"

"First, we need to conduct a comprehensive test on your genes, then identify the gene fragments in your genes that are related to systemic lupus erythematosus, and then perform in vitro cell culture."

"Is it similar to the breakthrough achieved last year in which stem cells were induced to become pancreatic islet cells and then transplanted in vivo?" He Youwei guessed.

Jiang Miao shook his head: "No, systemic lupus erythematosus is a problem with the immune system. Even if we use stem cells to cultivate immune cells, there is no way to transplant them. If we force a transplant, it may trigger a violent reaction from the body's immune system, which will then aggravate the condition."

He Youwei nodded, this possibility is indeed very high.

"My solution is to shut down part of your immunity. Systemic lupus erythematosus is an indiscriminate attack by immune cells on other cells in the body. Essentially, the immune system is overactive, and part of the immunity needs to be shut down."

"Can this really be done?" He Youwei was very shocked.

"You should take a look at my related papers." Jiang Miao reminded with a smile.

"Your paper?" He Youwei has been paying attention to relevant medical journals in recent years. As far as she can remember, Jiang Miao has never published any relevant papers in medical journals.

"The underlying biological logic of humans and fish is the same. When I was studying the artificial breeding technology of eels, I found many systematic associations of genes, some of which can be applied to humans. After all, the gene sequences of humans and eels are not much different. I have conducted research on my own genes. As long as a specific diet and medication are taken, people's immunity, vitality, and physical fitness can be enhanced to varying degrees."

“…” He Youwei was stunned.

Li Jianming, who was busy eating, didn't understand what the two were talking about at all. After all, he was a law major and had only a superficial understanding of this biomedical knowledge.

"I named this mechanism the systemicity of genes. A part of the gene sequence constitutes the genome, gene group, and gene family, which will produce specific functions. Intervening these genes in a specific way is somewhat similar to the systemic treatment of traditional Chinese medicine. Of course, due to confidentiality considerations, I only wrote part of the content in my paper."

At this time, He Youwei had understood: "Mr. Jiang discovered a specific gene combination rule, or a research method."

"That's right." Jiang Miao did discover the pattern.

After browsing the genes of hundreds of employees across the company and their thousands of relatives, as well as the genes of various animals and plants, Jiang Miao summarized 37 specific rules because he knew the functions of these gene fragments, genomes, gene groups, and gene families.

Through these rules, even if he loses the identification panel at this time, after detecting the genetic sequence of an Earth creature, he can analyze 99.9% of the corresponding functions of the creature's genes based on these genetic rules.

He had tried this before. Instead of using an identification panel, he used instruments to directly detect the genes of pigs, cows, sheep, mantises, cicadas, cobras, shrimps, barnacles, dandelions, and banyan trees. He then analyzed the genetic functions of these organisms based on genetic rules and compared them with the results of the identification panel.

The accuracy of the comparison results is between 97% and 99%. Some of the errors were caused by his lack of familiarity at the beginning. After he mastered these genetic rules, the accuracy has been maintained above 99%.

In fact, this is very normal.

After all, he already knew the answer and had no shortage of reference samples. It was naturally very easy to reverse the rules and formulas using these answers.

Let me give you an example.

This is like having successfully detonated a large number of atomic bombs and hydrogen bombs, and having a very good understanding of the structures of these atomic bombs and hydrogen bombs. At this time, it is too easy for you to summarize how to design atomic bombs and hydrogen bombs.

You know, when America developed the first atomic bomb, it mobilized an astronomical amount of manpower and material resources, but for later imitators, the difficulty of developing and manufacturing atomic bombs dropped sharply.

The most typical example is that America successfully detonated the world's first hydrogen bomb in 1952. Lucia followed closely and detonated a hydrogen bomb in a lasagna configuration in 1953. In 1955, she completed the real hydrogen bomb detonation, and it took only three years to catch up.

Sometimes, technology is like a piece of paper. As long as there is a successful example, it is relatively easy for other forces to catch up if they try their best.

For example, many people think that China’s lithography technology will never surpass ASML.

In fact, this is a wrong perception.

If China gives up everything and completely disregards international patent laws, it will soon catch up. Don't underestimate the only country in the world that has a complete industrial system.

The problem is that we now need to comply with international patent laws, and the patent moat built by ASML has blocked many technical routes, making it difficult for domestic lithography machines to move forward.

Even so, in September this year, domestic related companies completed the first deep ultraviolet lithography platform that can process 10-nanometer chips.

Jiang Miao first saw the complete answer and then reversed the rules and formulas, which naturally was not difficult.

But He Youwei didn't know that at this moment she had only one thought in her mind: if what Jiang Miao said was true, then there would be a lot of Nobel Prize-level achievements in front of her.

He Youwei asked, "Mr. Jiang, I heard that you are applying for an honorary doctorate. Are you interested in becoming a distinguished professor and doctoral supervisor at Wudaokou University? If your genetic laws can be verified, I can use my connections to get you approved quickly."

"I have promised Lion Rock Agricultural University that I will become a distinguished professor and doctoral supervisor at my alma mater."

"Oh?" He Youwei had already made up her mind. If Jiang Miao's genetic law really existed, then she would not intern at Union Hospital, but would apply to be Jiang Miao's doctoral student.

After all, if Jiang Miao's genetic laws are true, then he would be a golden thigh-level existence in the academic world.

If you don’t hold your thighs now, when will you wait?
(End of this chapter)