Chapter 245 Clinical Test

Chapter 245 Clinical Test

Chapter 245 Clinical Test (Super Large Cup)

Jiang Miao and his group took the high-speed rail to Chang'an, the core city in the northwest.

He did not go to Minqin County immediately, but stayed in Chang'an.

Because the phase III clinical trial he coordinated in July was approved at the end of August, and at the same time, Hailufeng Hospital also found three public hospitals to cooperate as pilot hospitals for clinical testing.

One of the public hospitals is in Chang'an City.

Jiang Miao happened to pass by Chang'an today, so he stopped and took a look at the clinical testing situation of this hospital.

"Hello, Professor He."

Professor He, the chief neurosurgeon of the hospital, also smiled and extended his hand: "Hello, Professor Jiang."

After shaking hands, Jiang Miao stood at the door of the ward and glanced at the patients inside through the crack of the door: "Professor He, how are the patients?"

"The situation is OK. One of the patients has been treated for 20 days, and the CT scan and laboratory test results are in line with expectations." Professor He took the medical report from his doctoral student:
"This patient has a relatively serious diffuse glioma, and the location is very troublesome. Surgery is likely to cause serious damage to brain function. If surgery is not performed, the tumor will grow rapidly and will soon compress the brain stem."

Several people have walked into the ward. Jiang Miao took a look at the medical records and then at the patient's condition: "Professor He is using cranial drainage surgery to treat the patient!"

Professor He nodded slightly. "Yes, Professor Jiang has a sharp eye. This is what I think. After the Yulin protein infects tumor cells, the patient's immune system will launch a fierce attack, which will cause a large area of ​​tumor cells to die. The location of the tumor that has already formed is relatively concentrated, and it is not convenient to remove it inside the brain. Therefore, I implanted the drainage tube into the tumor."

"I just observed that Professor He is worried that the patient's body cannot withstand the side effects, so he adopts a phased treatment plan?"

Professor He nodded again. At the same time, he was very surprised at Jiang Miao's medical level. He secretly exclaimed: There is no false reputation under such a great name.

"Professor Jiang hit the nail on the head. I did this because I was worried about the side effects of the treatment. After 20 days of exploration and experimentation, we have figured out part of the situation. Now we inject a certain amount of Yulin protein into the patient's cranial tumor every five days on average to infect a small number of tumor cells, allowing the patient's immune system to kill these tumor cells, and then suck the dead tumor cells out of the body through the drainage tube."

"What about the allergic reaction?"

"One patient had a severe allergic reaction, with a rash on his body, and needed medication to treat the allergic reaction. The other four patients had milder allergic reactions."

As for allergic reactions, Jiang Miao is very clear that the allergic reactions to Yulin protein are basically impossible to eliminate.

Because the therapeutic mechanism of Yulin protein is to infect tumor cells and induce the human immune system to attack tumor cells.

If Yulin protein does not have the property of causing allergies in the human body, its ability to induce the human immune system to attack tumor cells will be weakened, and it will not have any therapeutic effect.

In other words, Yulin protein is a double-edged sword.

To achieve therapeutic effects, patients must endure allergic reactions.

If there is no allergic reaction, it means that the body cannot recognize the "harmfulness" of yulin protein, causing the immune system to "silence" yulin protein and tumor cells infected by it.

Professor He also knows the reason: "The therapeutic mechanism of Yulin protein is bound to cause allergic reactions, but as long as the allergic reaction is not life-threatening, the benefits outweigh the harm."

Jiang Miao took the medical record, looked at it for a while, and asked in a low voice: "Professor He, do you know the cause of this patient's disease?"

"I'm not quite sure about this. What did Professor Jiang find?" Professor He did not dare to ignore Jiang Miao's opinion.

"Where are his family members?"

Hearing Jiang Miao's words, the intern doctoral student beside him quickly called the patient's family standing on the other side of the bed: "Mr. Li, this is Professor Jiang, the CEO of a new drug development company. He wants to know about your situation. You must answer truthfully."

The middle-aged man with wrinkles on his face came over and said nervously, "Hello, Professor Jiang. I am the patient's father. If you have any questions, please ask! I will answer them truthfully."

Jiang Miao glanced at the middle-aged man and frowned.

Seeing this scene, the middle-aged man became more and more nervous.

"Has your family renovated the house in recent years? Or moved into a new house?"

"Ah? Uh uh..." The middle-aged man was stunned for a moment, then answered truthfully: "Yes, my family just renovated the house two years ago."

“Do you use a lot of cheap synthetic wood in your home?”

"This..." The middle-aged man recalled, his face suddenly turned pale: "It's quite a lot..."

Jiang Miao shook his head: "After you go back, throw away all the synthetic wood furniture in your home. Either use plastic or iron products. I estimate that the formaldehyde and other harmful gases in your home are seriously exceeded. Don't be reluctant. Some cheap synthetic wood will continue to release formaldehyde and harmful gases for more than ten years."

"Okay, okay, Professor Jiang." The middle-aged man's head was pounding like a ball of garlic, his face was pale, and he was obviously frightened.

Jiang Miao knew very well that many people had no experience in decoration, or they were greedy for small profits and bought cheap materials.

Although many synthetic wood products on the market are marked as meeting formaldehyde emission standards, manufacturers will never tell you that a single product does meet the standards. However, once you use a large number of cheap synthetic wood products at home, the formaldehyde and harmful gases released by a large number of synthetic wood products that meet the standards indoors will be superimposed on each other, resulting in serious formaldehyde and harmful gas exceeding the standard problem.

An even more serious problem is that commercial housing nowadays is a very sealed environment, especially in winter, when the indoor environment is basically airtight. Under the heating of floor heating, many synthetic furniture and building materials will increase the release of formaldehyde and harmful gases.

To solve the problem of excessive formaldehyde and harmful gases in the room, either maintain good ventilation or abandon synthetic wood furniture and building materials and use materials such as plastic, solid wood, tiles, iron products, and aluminum alloy instead.

As for purchasing more expensive synthetic wood, the improvement effect is actually limited.

Because in the case of many individual synthetic wood furniture, most of them meet the standards.

However, if too much synthetic wood furniture and building materials are used in the same interior space, the result of the accumulation will definitely exceed the standard.

As for the so-called solid wood furniture, if the unit price is too low, don't expect to buy real solid wood. After all, the domestic natural wood production capacity is limited. The natural wood imported from abroad will be expensive after passing through several hands.

Especially for families with limited financial resources, they are likely to only be able to buy synthetic wood that impersonates solid wood. Instead of taking a chance, it is better to face the reality and buy iron and plastic furniture, which are safer and more cost-effective.

...

Accompanied by Professor He, Jiang Miao visited other patients participating in the test.

These patients all had diffuse gliomas.

Patients participating in clinical trials not only have their medical expenses covered by Hailufeng Company, but they will also receive an additional special subsidy of 10,000 yuan per month.

In fact, for these patients and their families, they are desperate and only try their best to save the situation.

After all, diffuse gliomas are too prone to recurrence and are often entangled with the brain, making them difficult to completely remove through surgery. They often recur again a few years after one operation.

If you are lucky, you can survive for more than ten years after one operation, and some patients can even survive for more than twenty years.

But if you are unlucky, it may even relapse in two or three years.

Every surgery is a huge adventure for patients with diffuse glioma, because diffuse glioma is entangled with the brain, and if the brain's neural structure and brain tissue are accidentally cut, it may cause various functional disorders in patients.

For example, after an operation, a person may lose his or her hearing, smell, or sight, or may become paralyzed and unable to coordinate movements, or even become a vegetable.

The treatment plan of Yulin protein is relatively safe. It does not require direct surgery to cut the tumor inside the cranial cavity. Instead, it kills the tumor cells through the body's immune system and retains normal cells.

The only troublesome thing is that the treatment process of Yulin protein needs to be carried out entirely in the hospital.

After all, Yulin protein can cause allergic reactions in patients. If they are not monitored at all times in the hospital, severe allergic reactions may cause the patient to die.

Another thing is that tumor cells are killed in the body. If too many tumor cells are eliminated in a short period of time, pus and blood will accumulate, which will lead to a serious inflammatory reaction.

This must be supported by auxiliary treatments such as drainage surgery and resection surgery.

For example, Professor He’s treatment plan involves surgically implanting a drainage tube and then using Yulin protein for treatment.

After visiting five cancer patients participating in the clinical trial, Jiang Miao held a small academic seminar in the hospital at the invitation of the hospital's director.

Considering that everyone didn't have much time, Jiang Miao didn't ask them to make special arrangements for it. Everyone ate together and participated in the symposium during lunch time.

"Professor Jiang, the food is simple, please forgive me." Dean Zhu Guozhi said with a smile.

Jiang Miao shook his head: "I also eat ordinary meals at home."

After eating half full, Jiang Miao got straight to the point: "Don't be too serious, let's just treat it as a conversation between friends, so I'll just throw out some ideas..."

"You may already know that I am engaged in breeding, so I know a thing or two about genetic technology. At present, there are many ideas about the treatment of tumors and the tumor microenvironment in the cutting-edge field. The discovery of Yulin protein this time is actually an unexpected result..."

Jiang Miao briefly explained the source of Yulin protein, and introduced to everyone the antibiotic that Hailufeng Company is currently conducting clinical trials on: Ankersu hydrochloride.

There are several reasons for this name.

Hydrochloric acid represents the process. After this antibiotic is produced from the bacterial extract, it must be treated with hydrochloric acid to make the drug more stable and reduce some side effects.

The meaning of Ankesu is that this antibiotic has the side effect of making patients drowsy, and it can also target many stubborn drug-resistant bacteria.

"Hello, Professor Jiang. I'm..." After introducing himself, a chief physician asked Jiang Miao, "I checked Professor Lin's paper some time ago. She and her student He Youwei mentioned a medical technology for treating lupus erythematosus in their paper. I want to know what the current development prospects of this technology are?"

Jiang Miao answered directly: "My wife and her student's research has actually verified the technology, because the student himself is a patient with lupus erythematosus."

“Has it been put into use?”

"Yes, clinical trials are currently being conducted within Hailufeng Hospital. A total of 50 patients have participated in the treatment, and the results are very good. These patients can now lead a normal life. As long as they take special medicines on a daily basis and pay attention to their diet, there will generally be no relapses." After hearing Jiang Miao's answer, several chief physicians in related fields discussed in a low voice.

The chief physician who asked the question just now asked curiously, "Professor Jiang, I have read this medical technology and related papers. I am afraid that it will cost a lot to develop a special medicine for patients, right?"

"The core cost in this regard is still the labor cost. Special medicines are mainly common drugs, nutrients, and natural plant extracts. Our hospital has a special special medicine configuration laboratory. Generally, the ingredients of the special medicine are determined, and later we just need to configure it according to this ratio."

Jiang Miao paused for a moment and continued, "In terms of fees, the initial genetic testing and drug preparation process will cost about 20,000 to 30,000 yuan, and the monthly drug cost will be about 300 to 400 yuan in the later period."

“After medical insurance?”

"We are a private hospital. There is no way for medical insurance to cover these charges." Jiang Miao shook his head.

"The monthly medicine cost is three or four hundred yuan, and the charge for using this specially formulated special medicine is really not high." A pharmacist whispered.

After all, a pharmacist who specializes in preparing medicines, plus various equipment, is a considerable expense.

Hailufeng Hospital offers such low charging standards in order to benefit patients as much as possible.

After all, the core formula ingredients of these special-effect medicines are common chemical drugs, nutrients, and plant extracts. These ingredients are of relatively fixed types, but the proportions of the special-effect medicine ingredients are slightly different.

In fact, the cost of the medicine is only a few dollars. The most important cost is the labor cost. Every time the medicine is dispensed, at least two specialized pharmacists are required. Add to that the ingredient testing, and this part of the cost adds up to almost more than a hundred dollars.

Taking into account expenses such as equipment depreciation, loss of drug reserves, and site fees, the gross profit margin of a specific drug for treating lupus erythematosus is only about 30% to 40%.

For the pharmaceutical industry, the profit is relatively small.

After all, this kind of medicine cannot be mass-produced and requires special medicines made by special people. The cost can be reduced to such a low level by various methods adopted by Hailufeng Company. If it follows the model of other pharmaceutical companies, the estimated monthly drug cost would be at least tens of thousands of yuan.

For drug ingredient testing alone, ordinary institutions charge a one-time fee starting at several thousand yuan.

According to the current experience of Hailufeng Hospital, under normal circumstances, a group of pharmacists can only dispense medicines to 384 patients each month, which means one patient every half an hour on average.

Based on a charging standard of around 350 yuan per person, the monthly revenue is 134400 yuan.

The salaries of two pharmacists plus other welfare expenses cost about 3 yuan per month, and other costs are about 6 yuan.

As the scope of treatment expands in the future, hundreds of professional dispensing pharmacists may be needed.

After all, the number of potential lupus patients in China has reached millions. Even if only one-tenth of these patients come to seek customized special medicines, the number would be in the hundreds of thousands.

If each patient takes three months' worth of medication each time, then at least 172 patients will come to buy special-effect drugs every month, which requires that the pharmaceutical dispensing laboratory must have at least pharmacists.

Of course, in the future, Hailufeng Hospital will definitely introduce fully automatic medicine dispensing and pharmaceutical equipment to reduce manpower expenditure in this area.

The doctors present at Hailufeng Hospital found this model very troublesome. After all, the one-person-one-prescription model meant that labor costs were difficult to control.

Jiang Miao also briefly introduced how to determine the genetic targets of lupus patients. Especially when they heard that some confidential technologies would be used, many doctors knew that this technology would probably be difficult to promote on a large scale.

In fact, the previous one-person-one-prescription model, coupled with the need for a specialized pharmacist to dispense the medicine, makes it difficult for many public hospitals to imitate.

Because in this case, the more patients there are, the more pharmacists and professional testing equipment the hospital needs to have, as well as large reserves of pharmaceutical raw materials.

In addition, professional gene target analysts are needed, and it will take two or three months to adjust the drug treatment plan. These situations are too complicated.

If there are not a large number of patients, the costs of equipment, personnel and raw materials cannot be covered.

However, if there are a large number of patients, the various applications for public hospitals will be more complicated, especially the application for increasing staffing, which generally will not be approved so quickly.

Therefore, even if we want to promote the popularization of this treatment technology, it is estimated that it will not be simply and crudely promoted to all hospitals.

Many doctors present thought of a cooperation model, that is, Hailufeng Hospital provides technical services and pharmaceutical services, and the local hospital does auxiliary work in the early stage.

For example, blood drawing, testing, monitoring of medication, etc., these can all be handed over to local hospitals. Hailufeng Hospital only needs to determine the patient's genetic targets and specific drug formulas. Once the specific drug formula is determined, it only needs to mail the drugs to the patient regularly.

There are plans to add a drug store mini program to the Hailufeng specialty store APP to customize drugs for patients.

As for the sale of this drug, it is certainly not that simple. Before obtaining special permission, patients can only come to Shanmei’s Hailufeng Hospital to buy it themselves. There is no way to purchase it online or by mail.

After all, it is difficult to apply for patents and drug marketing authorizations for these special medicines one by one, and they can only be supplied to patients in the form of special prescription drugs in hospitals.

The sale of special-effect drugs through APP must go through various strict approval procedures.

The management of drugs is a very strict matter.

Patients who live farther away can only get special medicines more conveniently after Hailufeng Hospital expands to the surrounding areas.

Currently there are only two Hailufeng hospitals, one is Shanmei Hailufeng Hospital and the other is Zhelimu Hailufeng Hospital. Other areas may need to wait for two or three years.

In fact, Hailufeng Company is also promoting the development of medical tourism and has built several professional sanatoriums in various parts of Shantou and the United States to specifically serve cancer patients and lupus patients from other places.

Although Yulin protein will certainly be sold on a large scale in the future, Jiang Miao is very clear that if Yulin protein is to achieve the greatest therapeutic effect, it is best to use autologous tumor cells as bacterial culture medium to allow Yulin protein to specialize in infecting the tumor cells.

The universal Yulin protein is only effective against most common tumor cells. Some tumor cells may be immune to the universal Yulin protein. At this time, a customized version of Yulin protein must be used.

To customize the special Yulin protein, the patient has to come to Hailufeng Hospital in person, undergo live tumor cell extraction, and then have the laboratory carry out special cultivation.

This is a relatively appropriate treatment option for those less common tumor types.

After all, there may be only dozens of patients with some rare types of tumors in the country. It is impossible for pharmaceutical companies to open a production line specifically for dozens of patients, and it is impossible for individual hospitals to purchase such drugs for stockpiling. They can only wait until patients come for treatment and find that the generic Yulin protein is ineffective, and then they will recommend them to come to Hailufeng Hospital for customized drugs.

In fact, even if it is universal Yulin protein, ordinary hospitals will not stock it.

As a special protein, it must be stored at low temperatures, and its shelf life is only about three or four months.

It is estimated that the treatment plan of various hospitals in the future will be to first conduct genetic testing on the patient's tumor cells, and after confirming that the tumor cells have corresponding gene targets, they will purchase universal Yulin protein from Xin Kangle Pharmaceutical.

If the test results do not show a receptor target for the universal Yulin protein, we can only recommend the patient to come to Hailufeng Hospital.

This is a more reasonable solution.

After all, the cost of small batches of customized Yulin protein produced in the laboratory will be relatively low. The production cost of the drug needed by each person is about a few thousand yuan.

Including other expenses, the total treatment cost for a single person can be reduced to less than 10 yuan, and the treatment time lasts one to two months.

Of course, this only applies to patients in the early and middle stages of cancer. If the patient is in the late stage of cancer, the cost will definitely not be low.

Because for patients with advanced cancer, it is not just a matter of eliminating cancer cells, but also of organ dysfunction.

For example, in advanced lung cancer, even if the cancer cells are eliminated, the lung tissue in the patient's body cannot recover. Complications such as pulmonary edema and pneumonia may even occur during treatment, which will most likely require a ventilator or even an artificial lung.

When organ-type tumors reach the late stage, the patient's organ function has often suffered irreversible damage, and it is really difficult to treat them at this time.

If possible, you can consider completely removing the cancerous organ, then performing an organ transplant, and then carrying out cancer-killing treatment simultaneously.

However, the rejection of allogeneic organ transplantation is currently very troublesome, and there are relatively few donated organs suitable for transplantation. Unless the organ cloning technology is successful and the cloned organs are sold at a relatively cheap price, the overall cost of treating patients with advanced cancer will definitely be high.

Jiang Miao communicated with the doctor of the hospital for more than an hour and then took the initiative to leave.

That afternoon, the group took the high-speed rail to Gansu Province again.

at the same time.

In Minqin High-tech Industrial Park.

Many related companies are also studying the silicon bean threads that were trial-produced on a small scale yesterday.

Some companies directly use silicone bean silk for weaving, and then use silicone bean silk thread to weave into the shapes of various parts, and then use the glue injection process to form special parts.

For example, at the Minqin Parts R&D Center of Panshi Auto, they will use silicon bean threads to weave the frame and shell, and then use special fire-resistant epoxy resin for glue injection, so that the frame can be formed in one piece.

In order to reduce weight, the entire frame uses a very dense hollow and core design.

The freshly-produced composite frame was immediately subjected to various impact, crushing, falling and burning tests.

Although the chassis material is mainly silicon bean silk, in order to enhance the overall fire resistance, researchers at the R&D center used silicon carbide tubes doped with fire-resistant epoxy resin as the bottom layer of the base material.

In the test site, even if the sponge shell is completely destroyed and the batteries are ignited, the flames still cannot burn the bottom plate of the chassis.

The silicon carbide tube with a special woven structure has very good heat conduction characteristics, so a special fast heat dissipation box is set on the upper rear part of the chassis of the silicon carbide tube.

This rapid cooling box contains ingredients similar to air-conditioning refrigerants, which can ensure that after combustion under the chassis, the temperature inside the car can at least be maintained within a relatively stable limit.

During the test, all batteries can burn at maximum capacity for about fifteen minutes, keeping the temperature in the car below 40 degrees Celsius to prevent the passengers from becoming barbecued meat on the teppanyaki grill.

(End of this chapter)